Article

Pharmacological Restoration of Visual Function in a Zebrafish Model of von-Hippel Lindau Disease

2018-12-04

Abstract excerpt

Von Hippel-Lindau (VHL) syndrome is rare, autosomal dominant disorder, characterized by hypervascularised tumour formation in multiple organ systems. Vision loss associated with retinal capillary hemangioblastomas remains one of the earliest complications of VHL disease. The mortality of Vhl -/- mice in utero restricted modelling of VHL disease in this mammalian model. Zebrafish harbouring a recessive germline m...

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Literature Corpus work: a801720e-d475-58bd-92c7-4429c112b534
DOI: 10.1101/485730

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