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Article

Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility.

Cancer research - 1 Apr 2010

Nicoloso Milena S, Sun Hao, Spizzo Riccardo, Kim Hyunsoo, Wickramasinghe Priyankara, Shimizu Masayoshi, Wojcik Sylwia E, Ferdin Jana, Kunej Tanja, Xiao Lianchun, Manoukian Siranoush, Secreto Giorgio, Ravagnani Fernando, Wang Xuemei, Radice Paolo, Croce Carlo M, Davuluri Ramana V, Calin George A

Abstract excerpt

Single-nucleotide polymorphisms (SNP) associated with polygenetic disorders, such as breast cancer (BC), can create, destroy, or modify microRNA (miRNA) binding sites; however, the extent to which SNPs interfere with miRNA gene regulation and affect cancer susceptibility remains largely unknown....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20332227
DOI: 10.1158/0008-5472.CAN-09-3541
PMCID: PMC2853025

Genes

BRCA1
TGFB1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20332227-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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