Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2016

Liu Hongliang, Gao Fengqin, Dahlstrom Kristina R, Li Guojun, Sturgis Erich M, Zevallos Jose P, Wei Qingyi, Liu Zhensheng

Abstract excerpt

DNA double-strand breaks (DSBs) are one of the most serious forms of DNA damage to the cell, causing genomic instability and ultimately carcinogenesis. In this study, we hypothesized that single nucleotide polymorphisms (SNPs) at the micro RNA (miRNA)-binding sites of DSB repair genes may influence cancer risk by dysregulating target gene expression. To test our hypothesis, we firstly performed functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group Proteins

Share to Head and Neck Neoplasms

Share to Neoplasm Staging

Share to Real-Time Polymerase Chain Reaction

Share to RNA Helicases

Share to ROC Curve

Source

Open in PubMed Open full text

Identifiers

PMID: 26711789
DOI: 10.1007/s13277-015-4682-6
PMCID: PMC4958391

Genes

BRIP1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck.PMID 26711789Read ↗

BRIP1 variations analysis reveals their relative importance as genetic susceptibility factor for cervical cancer.Semantic proximity Read ↗

First evidence for the contribution of the genetic variations of BRCA1-interacting protein 1 (BRIP1) to the genetic susceptibility of cervical cancer.Semantic proximity Read ↗

Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility.Semantic proximity Read ↗

Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls.Semantic proximity Read ↗

A catalog of polymorphisms falling in microRNA-binding regions of cancer genes.Semantic proximity Read ↗

Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility.Semantic proximity Read ↗

SNPs in microRNA binding sites as prognostic and predictive cancer biomarkers.Semantic proximity Read ↗

Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women.Semantic proximity Read ↗

MicroRNA binding-site polymorphisms as potential biomarkers of cancer risk.Semantic proximity Read ↗

[Regulatory Potential of SNP Markers in Genes of DNA Repair Systems].Semantic proximity Read ↗

Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.Semantic proximity Read ↗

The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.