Article
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
The Journal of infectious diseases - 1 May 2010
Mosbruger Timothy L, Duggal Priya, Goedert James J, Kirk Gregory D, Hoots W Keith, Tobler Leslie H, Busch Michael, Peters Marion G, Rosen Hugo R, Thomas David L, Thio Chloe L
Abstract excerpt
Human genetic variation is a determinant of recovery from acute hepatitis C virus (HCV) infection; however, to date, single-nucleotide polymorphisms (SNPs) in only a limited number of genes have been studied with respect to HCV clearance. We determined whether SNPs in 112 selected immune response genes are important for HCV clearance, by genotyping 1536 SNPs in a cohort of 343 persons with natural HCV clearance...
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