Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2011

Guyot Marie-Claude, Bosoi Ciprian M, Kharfallah Fares, Reynolds Annie, Drapeau Pierre, Justice Monica, Gros Philippe, Kibar Zoha

Abstract excerpt

Vangl2 forms part of the planar cell polarity signalling pathway and is the gene defective in the Looptail (Lp) mouse mutant. Two previously described alleles, Lp and Lp(m1Jus) , segregate in a semi-dominant fashion, with heterozygotes displaying the looped-tail appearance, while homozygotes show the neural tube defect called craniorachischisis. Here, we report a novel experimentally induced allele, Lp(m2Jus) ,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Body Patterning

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Polarity

Share to Embryo, Mammalian

Share to Embryo, Nonmammalian

Share to Mice, Mutant Strains

Share to Validation Studies as Topic

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21404367
DOI: 10.1002/dvdy.22577
PMCID: PMC3593115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.PMID 21404367Read ↗

Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.Semantic proximity Read ↗

Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation.Semantic proximity Read ↗

Loop-tail phenotype in heterozygous mice and neural tube defects in homozygous mice result from a nonsense mutation in the Vangl2 gene.Semantic proximity Read ↗

An expanding role of Vangl proteins in embryonic development.Semantic proximity Read ↗

Contribution of VANGL2 mutations to isolated neural tube defects.Semantic proximity Read ↗

Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development.Semantic proximity Read ↗

Genetic interaction between members of the Vangl family causes neural tube defects in mice.Semantic proximity Read ↗

The loop-tail mouse model displays open and closed caudal neural tube defects.Semantic proximity Read ↗

Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.Semantic proximity Read ↗

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.Semantic proximity Read ↗

The "vestigial tail" mouse; a new recessive mutation.Semantic proximity Read ↗

Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.