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Article

Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes.

Journal of molecular biology - 7 Jan 2005

Chen Yan, Ali Tariq, Todorovic Vesna, O'leary Joanne M, Kristina Downing A, Rifkin Daniel B

Abstract excerpt

Transforming growth factor beta (TGF-beta) is secreted primarily as a latent complex consisting of the TGF-beta homodimer, the TGF-beta propeptides (called the latency-associated protein or LAP) and the latent TGF-beta binding protein (LTBP). Mature TGF-beta remains associated with LAP by non-covalent interactions that block TGF-beta from binding to its receptor. Complex formation between LAP and LTBP is mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15567420
DOI: 10.1016/j.jmb.2004.10.039

Genes

LTBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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