Article

New tools to study the interaction between integrins and latent TGFβ1

2023-01-26

Abstract excerpt

Transforming growth factor beta (TGFβ) 1 regulates cell differentiation and proliferation in different physiological settings, but is also involved in fibrotic progression and protects tumors from the immune system. Integrin αVβ6 has been shown to activate latent TGFβ1 by applying mechanical forces onto the latency-associated peptide (LAP). While the extracellular binding between αVβ6 and LAP1 is well characterize...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2ec6977-4f48-5c5d-a007-c52d4da745b2
DOI: 10.1101/2023.01.26.525682

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

New tools to study the interaction between integrins and latent TGFβ1DOI 10.1101/2023.01.26.525682Read

Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin.Semantic proximity Read

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1Semantic proximity Read

Structural determinants of integrin β-subunit specificity for latent TGF-β.Semantic proximity Read

The α <sub>v</sub> β <sub>1</sub> integrin plays a critical in vivo role in tissue fibrosisSemantic proximity Read

Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex.Semantic proximity Read

LFA-1 in T Cell Migration and DifferentiationSemantic proximity Read

Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid ArthritisSemantic proximity Read

Structural analysis of peptide binding to integrins for cancer detection and treatmentSemantic proximity Read

Collagen Receptor Integrins: Rising to the ChallengeSemantic proximity Read

Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis.Semantic proximity Read

Pairing of integrins with ECM proteins determines migrasome formationSemantic proximity Read

Latent TGF-β structure and activation.Semantic proximity Read