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Article

Modulation of TGF-beta activity by latent TGF-beta-binding protein 1 in human malignant glioma cells.

International journal of cancer - 1 Aug 2009

Tritschler Isabel, Gramatzki Dorothee, Capper David, Mittelbronn Michel, Meyermann Richard, Saharinen Juha, Wick Wolfgang, Keski-Oja Jorma, Weller Michael

Abstract excerpt

High biological activity of the transforming growth factor (TGF)-beta-Smad pathway characterizes the malignant phenotype of malignant gliomas and confers poor prognosis to glioma patients. Accordingly, TGF-beta has become a novel target for the experimental treatment of these tumors. TGF-beta is processed by furin-like proteases (FLP) and secreted from cells in a latent complex with its processed propeptide, the...

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Source

Identifiers

PMID: 19431147
DOI: 10.1002/ijc.24443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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