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Article

An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse.

Genetics - 1 Aug 2003

Percec Ivona, Thorvaldsen Joanne L, Plenge Robert M, Krapp Christopher J, Nadeau Joseph H, Willard Huntington F, Bartolomei Marisa S

Abstract excerpt

The mammalian epigenetic phenomena of X inactivation and genomic imprinting are incompletely understood. X inactivation equalizes X-linked expression between males and females by silencing genes on one X chromosome during female embryogenesis. Genomic imprinting functionally distinguishes the parental genomes, resulting in parent-specific monoallelic expression of particular genes. N-ethyl-N-nitrosourea (ENU)...

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Identifiers

PMID: 12930754
DOI: 10.1093/genetics/164.4.1481
PMCID: PMC1462673

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Source receipt: pubmed, retrieved 7 Sept 2026.

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