Article
Induction of gene mutations in mice: the multiple endpoint approach.
Mutation research - 1 Jan 2000
Ehling U H, Charles D J, Favor J, Graw J, Kratochvilova J, Neuhäuser-Klaus A, Pretsch W
Abstract excerpt
The multiple endpoint mammalian mutagenesis approach developed in our institute screens in the same animal for recessive specific-locus alleles at 7 loci, approximately 30 loci coding for dominant-cataract mutations, 23 loci controlling protein-charge changes and 12 loci for enzyme-activity alterations. Experiments to screen for the approximately 70 loci in the same offspring of treated male mice were performed...
Topics
- Animals
- Cataract
- Ethylnitrosourea
- Female
- Genes, Dominant
- Isoelectric Point
- Male
- Mice
- Mutagenicity Tests
- Mutation
- Procarbazine
- Proteins