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Article

New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.

PloS one - 18 Mar 2010

Nakajima Masahiro, Takahashi Atsushi, Kou Ikuyo, Rodriguez-Fontenla Cristina, Gomez-Reino Juan J, Furuichi Tatsuya, Dai Jin, Sudo Akihiro, Uchida Atsumasa, Fukui Naoshi, Kubo Michiaki, Kamatani Naoyuki, Tsunoda Tatsuhiko, Malizos Konstantinos N, Tsezou Aspasia, Gonzalez Antonio, Nakamura Yusuke, Ikegawa Shiro

Abstract excerpt

Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262)...

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Identifiers

PMID: 20305777
DOI: 10.1371/journal.pone.0009723
PMCID: PMC2841168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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