Article
Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.
PloS one - 1 Jan 2011
Valdes Ana M, Styrkarsdottir Unnur, Doherty Michael, Morris David L, Mangino Massimo, Tamm Agu, Doherty Sally A, Kisand Kalle, Kerna Irina, Tamm Ann, Wheeler Margaret, Maciewicz Rose A, Zhang Weiya, Muir Kenneth R, Dennison Elaine M, Hart Deborah J, Metrustry Sarah, Jonsdottir Ingileif, Jonsson Gudbjorn F, Jonsson Helgi, Ingvarsson Thorvaldur, Cooper Cyrus, Vyse Timothy J, Spector Tim D, Stefansson Kari, Arden Nigel K
Abstract excerpt
Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and deriving from a genome wide association scan (GWAS) of knee OA in Japanese populations. The frequencies for rs10947262 were compared in 36,408 controls and 5,749...
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