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Article

Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function.

The Journal of biological chemistry - 21 May 2010

Owens Róisín M, Gu Xiaoling, Shin Miran, Springer Timothy A, Jin Moonsoo M

Abstract excerpt

The immunoglobulin (Ig) superfamily is one of the largest families in the vertebrate genome, found most frequently in cell surface molecules. Intercellular adhesion molecule-1 (ICAM-1) contains five extracellular Ig superfamily domains (D1-D5) of which the first domain, D1, is the binding site for the integrin lymphocyte function-associated antigen-1 (LFA-1) and human rhinovirus. Despite the modular nature of...

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Identifiers

PMID: 20304924
DOI: 10.1074/jbc.M110.104349
PMCID: PMC2871458

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Source receipt: pubmed, retrieved 7 Sept 2026.

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