Article
Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule.
Journal of virology - 1 Sept 2004
Xiao Chuan, Tuthill Tobias J, Bator Kelly Carol M, Challinor Lisa J, Chipman Paul R, Killington Richard A, Rowlands David J, Craig Alister, Rossmann Michael G
Abstract excerpt
Intercellular adhesion molecule 1 (ICAM-1) is the cellular receptor for the major group of human rhinovirus serotypes, including human rhinovirus 14 (HRV14) and HRV16. A naturally occurring variant of ICAM-1, ICAM-1Kilifi, has altered binding characteristics with respect to different HRV serotypes. HRV14 binds to ICAM-1 only transiently at physiological temperatures but forms a stable complex with ICAM-1Kilifi....
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