Article
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus.
Cell - 20 Apr 1990
Staunton D E, Dustin M L, Erickson H P, Springer T A
Abstract excerpt
Intercellular adhesion molecule 1 (ICAM-1, CD54) binds to the integrin LFA-1 (CD11a/CD18), promoting cell adhesion in immune and inflammatory reactions. ICAM-1 is also subverted as a receptor by the major group of rhinoviruses. Electron micrographs show that ICAM-1 is a bent rod, 18.7 nm long, suggesting a model in which the five immunoglobulin-like domains are oriented head to tail at a small angle to the rod...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- Antigens, Differentiation
- Cell Adhesion Molecules
- Cell Line
- Chimera
- Chromosome Deletion
- Humans
- Immunoglobulins
- Intercellular Adhesion Molecule-1