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Article

High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.

The Journal of urology - 1 May 2010

Hains David S, Sims-Lucas Sunder, Carpenter Ashley, Saha Monalee, Murawski Inga, Kish Kayle, Gupta Indra, McHugh Kirk, Bates Carlton M

Abstract excerpt

PURPOSE: Mice with Fgfr2 conditional deletion in metanephric mesenchyma (Fgfr2(Mes-/-)) have ureteral bud induction abnormalities. We determined whether Fgfr2(Mes-/-) mutants developed abnormally positioned ureters predisposing to vesicoureteral reflux. MATERIALS AND METHODS: We measured common nephric duct length and assayed for apoptosis in embryonic day 11.5 mice. We performed 3-dimensional reconstruction of,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20303521
DOI: 10.1016/j.juro.2009.12.095
PMCID: PMC3657704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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