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Article

Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma.

Pediatric research - 1 Sept 2020

Anslow Melissa J, Bodnar Andrew J, Cerqueira Débora M, Bushnell Daniel, Shrom Brynn E, Sims-Lucas Sunder, Bates Carlton M, Ho Jacqueline

Abstract excerpt

BACKGROUND: Vesicoureteral reflux (VUR), backflow of urine into the kidney, is associated with urinary tract infections and chronic kidney disease. Integrity of the vesicoureteral junction (VUJ), where reflux occurs, is determined largely by proper induction of the ureteric bud from the Wolffian duct. Induction is modulated by signals from the surrounding peri-Wolffian duct stroma. We evaluated whether miRNAs in...

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Identifiers

PMID: 32015493
DOI: 10.1038/s41390-020-0788-7
PMCID: PMC7396288

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