Article
No association of the C>T polymorphism that is located 1385 upstream from initial code of fibroblast growth factor 1 gene with Alzheimer's disease in Chinese.
Brain research - 30 Apr 2010
Bian Jian-Tao, Zhao Hua-Lu, Zhang Zhen-Xin, Bi Xiu-Hua, Zhang Jun-Wu
Abstract excerpt
Several lines of evidence indicate that fibroblast growth factor 1 (FGF1) confers neuroprotection against excitotocity and contributes to the selective vulnerability of neurons in entorhinal cortex in Alzheimer's disease (AD). Especially, FGF1 is related to Apolipoprotein E (ApoE) expression in reactive astrocytes. Therefore, FGF1 is a promising candidate gene for AD. Two studies reported the association of a...
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