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Article

Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease.

Biochemical and biophysical research communications - 20 Aug 2004

Yamagata Hidehisa, Chen Yusen, Akatsu Hiroyasu, Kamino Kouzin, Ito Jin-ichi, Yokoyama Shinji, Yamamoto Takayuki, Kosaka Kenji, Miki Tetsuro, Kondo Ikuko

Abstract excerpt

Fibroblast growth factor 1 (FGF1, also known as acidic FGF) protects selective neuronal populations against neurotoxic effects such as those in Alzheimer's disease (AD) and HIV encephalitis. The FGF1 gene is therefore a strong candidate gene for AD. Using the promoter polymorphism of the FGF1 gene, we examined the relationship between AD and the FGF1 and apolipoprotein E (APOE) genes in 100 Japanese...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15358178
DOI: 10.1016/j.bbrc.2004.06.142

Genes

FGF1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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