Article
Possible influence of a non-synonymous polymorphism located in the NGF precursor on susceptibility to late-onset Alzheimer's disease and mild cognitive impairment.
Journal of Alzheimer's disease : JAD - 1 Jan 2012
Di Maria Emilio, Giorgio Elisa, Uliana Vera, Bonvicini Cristian, Faravelli Francesca, Cammarata Sergio, Novello Maria Cristina, Galimberti Daniela, Scarpini Elio, Zanetti Orazio, Gennarelli Massimo, Tabaton Massimo
Abstract excerpt
The complex network of neurotrophic factors is supposed to play a role in neurodegeneration, but the effect of variations in their coding genes on susceptibility to sporadic Alzheimer's disease is not established. The mature form of nerve growth factor (NGF) derives from a precursor, proNGF, whic...
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