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Article

Thiol-enhanced decomposition of MNNG, ENNG, and nitrosocimetidine: relationship to mutagenicity in V79 Chinese hamster cells.

Carcinogenesis - 1 May 1991

Romert L, Swedmark S, Jenssen D

Abstract excerpt

The nitrosated form of cimetidine (Tagamet), nitrosocimetidine (NC), belongs to a group of nitrosoamidines in which the mutagenic and carcinogenic properties of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) have been studied in detail. The common mecha...

Topics

Animals
Carcinogens
Cell Line
Cimetidine
Cricetinae
Cricetulus
Methylnitronitrosoguanidine
Mutagenicity Tests
Mutation
Sulfhydryl Compounds
Thioguanine

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Identifiers

PMID: 2029748
DOI: 10.1093/carcin/12.5.847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2029748-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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