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Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.

Chemical research in toxicology - 1 Oct 2005

Totsuka Yukari, Nishigaki Rena, Enomoto Shigeki, Takamura-Enya Takeji, Masumura Ken-ichi, Nohmi Takehiko, Kawahara Nobuo, Sugimura Takashi, Wakabayashi Keiji

Abstract excerpt

A kind of N-nitrosobile acid conjugate, N-nitrosotaurocholic acid (NO-TCA), was incubated with calf thymus DNA, and formation of an adduct was detected by the 32P-postlabeling method under nuclease P1 conditions. To examine the nucleotides containing the adduct from NO-TCA, each of 2'-deoxyribonucleotide 3'-monophosphates (3'-dAp, 3'-dGp, 3'-dCp, or 3'-Tp) was incubated with NO-TCA. The same adduct spot was...

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PMID: 16533019
DOI: 10.1021/tx050144x

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