Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.

doi:10.1021/tx050144x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.

Chemical research in toxicology - 1 Oct 2005

Totsuka Yukari, Nishigaki Rena, Enomoto Shigeki, Takamura-Enya Takeji, Masumura Ken-ichi, Nohmi Takehiko, Kawahara Nobuo, Sugimura Takashi, Wakabayashi Keiji

Abstract excerpt

A kind of N-nitrosobile acid conjugate, N-nitrosotaurocholic acid (NO-TCA), was incubated with calf thymus DNA, and formation of an adduct was detected by the 32P-postlabeling method under nuclease P1 conditions. To examine the nucleotides containing the adduct from NO-TCA, each of 2'-deoxyribonucleotide 3'-monophosphates (3'-dAp, 3'-dGp, 3'-dCp, or 3'-Tp) was incubated with NO-TCA. The same adduct spot was...

Topics

Alkanesulfonates
Animals
Bile Acids and Salts
DNA Adducts
Gastrointestinal Tract
Male
Mutagens
Mutation
Nitrosamines
Rats
Rats, Wistar
Salmonella typhimurium
Taurodeoxycholic Acid

Source

Open in PubMed

Identifiers

PMID: 16533019
DOI: 10.1021/tx050144x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics