Article
Apparent mutagenicity of N-nitrosothiazolidine caused by a trace contaminant.
Mutation research - 1 Jan 2000
Miller A J, Pensabene J W, Doerr R C, Fiddler W
Abstract excerpt
The identification of N-nitrosothiazolidine (NTHZ) in smoked meat products prompted us to evaluate this compound for mutagenicity by the Salmonella assay. NTHZ was prepared in 99 + % purity by the nitrosation of the cysteamine-formaldehyde reaction mixture without isolation and purification of the resulting amine, and from thiazolidine, directly. Mutagenic activity was observed with TA100 without metabolic...
Topics
- Animals
- Biotransformation
- Cysteamine
- Meat
- Mutation
- Nitroso Compounds
- Rats
- Salmonella typhimurium
- Thiazoles