Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of C4 null alleles on C4 activation in systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Apr 1991

Briggs D C, Senaldi G, Isenberg D A, Welsh K I, Vergani D

Abstract excerpt

Deficiencies of early components of the classical complement pathway are known to be associated with systemic lupus erythematosus (SLE). C4 null alleles, C4A Q0 and C4B Q0, are prime candidates for the major histocompatibility complex associated factor which determines susceptibility to SLE. There is poor correlation, however, between the presence of low concentrations of C4 and possession of C4 null alleles, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Complement C4
Share to Complement C4a

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Complement C4b

Share to Gene Expression

Share to Lupus Erythematosus, Systemic

Share to Peptide Fragments

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 2029208
DOI: 10.1136/ard.50.4.251
PMCID: PMC1004396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of C4 null alleles on C4 activation in systemic lupus erythematosus.PMID 2029208Read ↗

Impact of Homozygous C4A Deficiency on Clinical Presentation of Systemic Lupus Erythematosus.Semantic proximity Read ↗

Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Relative contributions of HLA-DQA and complement C4A loci in determining susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

Major histocompatibility complex (MHC) complement deficiency, ancestral haplotypes and systemic lupus erythematosus (SLE): C4 deficiency explains some but not all of the influence of the MHC.Semantic proximity Read ↗

The importance of C4A null genes in Norwegian patients with systemic lupus erythematosus.Semantic proximity Read ↗

C4 null alleles in childhood onset systemic lupus erythematosus. Is there any relationship with renal disease?Semantic proximity Read ↗

Deficiency of C4A is a genetic determinant of systemic lupus erythematosus in three ethnic groups.Semantic proximity Read ↗

Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population.Semantic proximity Read ↗

Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).Semantic proximity Read ↗

Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects.Semantic proximity Read ↗

Measurement of erythrocyte C4d and complement receptor 1 in systemic lupus erythematosusSemantic proximity Read ↗

Circulating immune complexes and complement C4 null alleles in patients in patients operated on for premature atherosclerotic peripheral vascular disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.