Influence of C4 null alleles on C4 activation in systemic lupus erythematosus.

doi:10.1136/ard.50.4.251

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Article

Influence of C4 null alleles on C4 activation in systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Apr 1991

Briggs D C, Senaldi G, Isenberg D A, Welsh K I, Vergani D

Abstract excerpt

Deficiencies of early components of the classical complement pathway are known to be associated with systemic lupus erythematosus (SLE). C4 null alleles, C4A Q0 and C4B Q0, are prime candidates for the major histocompatibility complex associated factor which determines susceptibility to SLE. Ther...

Topics

Alleles
Complement Activation
Complement C4
Complement C4a
Complement C4b
Gene Expression
Humans
Lupus Erythematosus, Systemic
Nephelometry and Turbidimetry
Peptide Fragments
Phenotype

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