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Article

Measurement of erythrocyte C4d and complement receptor 1 in systemic lupus erythematosus

1 Nov 2004

Abstract excerpt

OBJECTIVE: C4-derived activation fragments are the only complement ligands present on the surfaces of normal erythrocytes. The significance of this observation is unknown, and the role of erythrocyte-bound C4 (E-C4) in human disease has not been explored. More than any other human disease, the pathogenesis of systemic lupus erythematosus (SLE) has been characterized by defects in clearance of complement-bearing...

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PMID: 15529364
DOI: 10.1002/art.20561

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