Article
Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Aug 1998
Naves M, Hajeer A H, Teh L S, Davies E J, Ordi-Ros J, Perez-Pemen P, Vilardel-Tarres M, Thomson W, Worthington J, Ollier W E
Abstract excerpt
Genetic susceptibility to systemic lupus erythematosus (SLE) may vary amongst different populations. In UK patients, genes encoded in the HLA class II (DQA*0501/DRB1*0301) and class III [C4A*Q0 and tumour necrosis factor (TNF) polymorphisms] subregions appear to contribute to disease susceptibility. We have examined HLA-DRB1, C4 and TNF microsatellites in 50 Spanish SLE patients and 48 matched controls....
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