Genetic and molecular biological characterization of a vaccinia virus gene which renders the virus dependent on isatin-beta-thiosemicarbazone (IBT).

doi:10.1016/0042-6822(91)90585-y

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Article

Genetic and molecular biological characterization of a vaccinia virus gene which renders the virus dependent on isatin-beta-thiosemicarbazone (IBT).

Virology - 1 Jun 1991

Meis R J, Condit R C

Abstract excerpt

We have sequenced and analyzed the transcription of a gene capable of rendering vaccinia virus (VV) dependent upon isatin-beta-thiosemicarbazone (IBT) for growth. Marker rescue analysis of an IBT-dependent mutant of VV, IBTd-1, and a temperature-sensitive mutant of VV, ts56, both of which require...

Topics

Adenine Nucleotides
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Cell Line
Chromosome Deletion
Chromosome Mapping
Cloning, Molecular
Genes, Viral
Genetic Complementation Test
Isatin
Molecular Sequence Data
Mutation
Oligoribonucleotides
RNA, Messenger
RNA, Viral
Restriction Mapping

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Identifiers

PMID: 2024483
DOI: 10.1016/0042-6822(91)90585-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2024483-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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