Article

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

2021-05-30

Abstract excerpt

As global life expectancy continues to climb, maintaining skeletal muscle function is increasingly essential to ensure a good life quality for aging populations. Calorie restriction (CR) is the most potent and reproducible intervention to extend health and lifespan, but is largely unachievable in humans. Therefore, identification of “CR mimetics” has received much attention. CR targets nutrient-sensing pathways ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3255507-e559-5a56-8ce4-6d51027e0adb
DOI: 10.1101/2021.05.28.446097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscleDOI 10.1101/2021.05.28.446097Read

Manipulation of health span and function by dietary caloric restriction mimeticsSemantic proximity Read

Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young MiceSemantic proximity Read

mTOR and Aging: An Old Fashioned DressSemantic proximity Read

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.Semantic proximity Read

Calorie restriction as an intervention in ageingSemantic proximity Read

Systematic transcriptomics analysis of calorie restriction and rapamycin unveils their synergistic interaction in prolonging cellular lifespanSemantic proximity Read

Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia.Semantic proximity Read

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and LongevitySemantic proximity Read

Safety and efficacy of rapamycin on healthspan metrics after one year: PEARL Trial ResultsSemantic proximity Read

Dietary restriction and the pursuit of effective mimetics.Semantic proximity Read

Rapamycin extends murine lifespan but has limited effects on aging.Semantic proximity Read

Calorie restriction in humans inhibits the <scp>PI</scp>3<scp>K</scp>/<scp>AKT</scp> pathway and induces a younger transcription profileSemantic proximity Read