Article
Podocyte-specific NF-κB inhibition ameliorates proteinuria in adriamycin-induced nephropathy in mice.
Clinical and experimental nephrology - 1 Feb 2017
Yamashita Maho, Yoshida Tadashi, Suzuki Sayuri, Homma Koichiro, Hayashi Matsuhiko
Abstract excerpt
BACKGROUND: Podocytes play a central role in the formation of the glomerular filtration barrier in the kidney, and their dysfunction has been shown to result in proteinuria. In the present study, we sought to determine the cell-autonomous role of NF-κB, a proinflammatory signaling, within podocytes in proteinuric kidney disease. METHODS: Podocyte-specific IκBΔN transgenic (Pod-IκBΔN) mice, in which NF-κB was...
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