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Article

Essential Role of Integrin-Linked Kinase in Podocyte Biology

12 Jul 2006

Abstract excerpt

Integrin-linked kinase (ILK) has been implicated in the pathogenesis of proteinuria and congenital nephrotic syndrome. However, the function of ILK in glomerular podocyte in a physiologic setting remains unknown. In this study, a mouse model was generated in which ILK gene was selectively disrupted in podocytes by using the Cre-LoxP system. Podocyte-specific ablation of ILK resulted in heavy albuminuria,...

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PMID: 16837631
DOI: 10.1681/asn.2006010033

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