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Article

Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival.

The Journal of biological chemistry - 22 Jul 2011

Kato Hideki, Gruenwald Antje, Suh Jung Hee, Miner Jeffrey H, Barisoni-Thomas Laura, Taketo Makoto M, Faul Christian, Millar Sarah E, Holzman Lawrence B, Susztak Katalin

Abstract excerpt

Diabetic kidney disease (DKD) is the single most common cause of albuminuria and end-stage kidney disease in the United States. We found increased expression of Wnt/β-catenin (Ctnnb1) pathway transcripts and proteins in glomeruli and podocytes of patients and mouse models of DKD. Mice with podocyte-specific expression of stabilized Ctnnb1 exhibited basement membrane abnormalities, albuminuria, and increased...

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Identifiers

PMID: 21613219
DOI: 10.1074/jbc.M111.223164
PMCID: PMC3138306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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