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Spatially patterned matrix elasticity directs stem cell fate

19 Jul 2016

Abstract excerpt

There is a growing appreciation for the functional role of matrix mechanics in regulating stem cell self-renewal and differentiation processes. However, it is largely unknown how subcellular, spatial mechanical variations in the local extracellular environment mediate intracellular signal transduction and direct cell fate. Here, the effect of spatial distribution, magnitude, and organization of subcellular matrix...

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PMID: 27436901
DOI: 10.1073/pnas.1609731113

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