Article
Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.
The Journal of biological chemistry - 26 Mar 2004
Mohler Peter J, Davis Jonathan Q, Davis Lydia H, Hoffman Janis A, Michaely Peter, Bennett Vann
Abstract excerpt
The molecular mechanisms required for inositol 1,4,5-trisphosphate receptor (InsP(3)R) targeting to specialized endoplasmic reticulum membrane domains are unknown. We report here a direct, high affinity interaction between InsP(3)R and ankyrin-B and demonstrate that this association is critical f...
Topics
- Animals
- Animals, Newborn
- Ankyrins
- Brain
- Calcium Channels
- Cattle
- Cell Line
- Cell Membrane
- Dose-Response Relationship, Drug
- Endoplasmic Reticulum
- Green Fluorescent Proteins
- Humans
- Inositol 1,4,5-Trisphosphate Receptors
- Kinetics
- Luminescent Proteins
- Mice
- Microscopy, Fluorescence
- Models, Molecular