Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity.

doi:10.1038/s44320-025-00092-7

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Article

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity.

Molecular systems biology - 1 Apr 2025

Ector Carolin, Didier Jeff, De Landtsheer Sébastien, Nordentoft Malthe S, Schmal Christoph, Keilholz Ulrich, Herzel Hanspeter, Kramer Achim, Sauter Thomas, Granada Adrián E

Abstract excerpt

The circadian clock regulates key physiological processes, including cellular responses to DNA damage. Circadian-based therapeutic strategies optimize treatment timing to enhance drug efficacy and minimize side effects, offering potential for precision cancer treatment. However, applying these st...

Topics

Humans
Breast Neoplasms
Circadian Clocks
Female
Cell Line, Tumor
Antineoplastic Agents
Circadian Rhythm
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 39994450
DOI: 10.1038/s44320-025-00092-7
PMCID: PMC11965565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-39994450-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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