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Article

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity.

Molecular systems biology - 1 Apr 2025

Ector Carolin, Didier Jeff, De Landtsheer Sébastien, Nordentoft Malthe S, Schmal Christoph, Keilholz Ulrich, Herzel Hanspeter, Kramer Achim, Sauter Thomas, Granada Adrián E

Abstract excerpt

The circadian clock regulates key physiological processes, including cellular responses to DNA damage. Circadian-based therapeutic strategies optimize treatment timing to enhance drug efficacy and minimize side effects, offering potential for precision cancer treatment. However, applying these strategies in cancer remains limited due to a lack of understanding of the clock's function across cancer types and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39994450
DOI: 10.1038/s44320-025-00092-7
PMCID: PMC11965565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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