Article
Distribution of CFTR variations in an Indonesian enteric fever cohort.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 May 2010
van de Vosse Esther, de Visser Adriëtte W, Al-Attar Sinan, Vossen Rolf, Ali Soegianto, van Dissel Jaap T
Abstract excerpt
BACKGROUND: Enteric fever is defined by circulating Salmonella serotype Typhi or Paratyphi in the blood. The first step in developing enteric fever is internalization of salmonellae in the gut epithelium. In in vitro experiments, attachment of S. Typhi to the cystic fibrosis transmembrane conductance regulator (CFTR) on the intestinal mucosa is crucial for bacterial uptake. We recently found a microsatellite...
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