Article
Susceptibility to typhoid fever is associated with a polymorphism in the cystic fibrosis transmembrane conductance regulator (CFTR).
Human genetics - 1 Oct 2005
van de Vosse Esther, Ali Soegianto, de Visser Adriëtte W, Surjadi Charles, Widjaja Suwandhi, Vollaard Albert M, van Dissel Jaap T
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is the affected protein in cystic fibrosis (CF). The high rate of CF carriers has led to speculation that there must be, similar to the sickle cell haemoglobin advantage in malaria, a selective advantage for heterozygotes. Such a selective advantage may be conferred through reduced attachment of Salmonella typhi to intestinal mucosa, thus providing...
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