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Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.

Infection and immunity - 21 Apr 2022

Barton Amber, Hill Jennifer, Bibi Sagida, Chen Liye, Jones Claire, Jones Elizabeth, Camara Susana, Shrestha Sonu, Jin Celina, Gibani Malick M, Dobinson Hazel, Waddington Claire, Darton Thomas C, Blohmke Christoph J, Pollard Andrew J

Abstract excerpt

Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Human challenge participants were genotyped by Illumina OmniExpress-24 BeadChip array (n = 176) and/or transcriptionally profiled by RNA sequencing...

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Identifiers

PMID: 35254093
DOI: 10.1128/iai.00389-21
PMCID: PMC9022534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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