Article
Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease.
Inflammatory bowel diseases - 1 May 2007
Bresso Francesca, Askling Johan, Astegiano Marco, Demarchi Brunello, Sapone Nicoletta, Rizzetto Mario, Gionchetti Paolo, Lammers Karen M, de Leone Annalisa, Riegler Gabriele, Nimmo Elaine R, Drummond Hazel, Noble Colin, Torkvist Leif, Ekbom Anders, Zucchelli Marco, Lofberg Robert, Satsangi Jack, Pettersson Sven, D'Amato Mauro
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) is an epithelial barrier disease that is thought to result from a dysregulated interaction with bacteria in the intestine of genetically predisposed individuals. The cystic fibrosis transmembrane conductance regulator (CFTR), which is mutated in the autosomal recessive disease cystic fibrosis, modulates gut permeability, mucus production, and epithelial interactions...
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