Article
Salmonella typhi uses CFTR to enter intestinal epithelial cells.
Nature - 7 May 1998
Pier G B, Grout M, Zaidi T, Meluleni G, Mueschenborn S S, Banting G, Ratcliff R, Evans M J, Colledge W H
Abstract excerpt
Homozygous mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF). In the heterozygous state, increased resistance to infectious diseases may maintain mutant CFTR alleles at high levels in selected populations. Here we investigate whether typhoid fever could be one such disease. The disease is initiated when Salmonella typhi enters gastrointestinal epithelial cells...
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