Article
Impact of genetic background on allele selection in a highly mutable Candida albicans gene, PNG2.
PloS one - 9 Mar 2010
Zhang Ningxin, Cannon Richard D, Holland Barbara R, Patchett Mark L, Schmid Jan
Abstract excerpt
In many microbes rapid mutation of highly mutable contingency genes continually replenishes a pool of variant alleles from which the most suitable are selected, assisting in rapid adaptation and evasion of the immune response. In some contingency genes mutability is achieved through DNA repeats within the coding region. The fungal human pathogen Candida albicans has 2600 repeat-containing ORFs. For those...
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