Article
Distribution of mutations distinguishing the most prevalent disease-causing Candida albicans genotype from other genotypes.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2009
Zhang Ningxin, Upritchard Jenine E, Holland Barbara R, Fenton Lauren E, Ferguson Martin M, Cannon Richard D, Schmid Jan
Abstract excerpt
Candida albicans is a major opportunistic pathogen of humans. Previous work has demonstrated the existence of a general-purpose genotype (GPG; equivalent to clade 1 as defined by multi-locus sequence typing data) that is more frequent than other genotypes as an agent of human disease and commensal colonization. We undertook a genomic screen which indicated that a large number of mutations differentiate GPG...
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