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Article

Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage.

mBio - 24 Mar 2020

Green Luke R, Al-Rubaiawi Ali A, Al-Maeni Mohammad A R M, Harrison Odile B, Blades Matthew, Oldfield Neil J, Turner David P J, Maiden Martin C J, Bayliss Christopher D

Abstract excerpt

Host persistence of bacteria is facilitated by mutational and recombinatorial processes that counteract loss of genetic variation during transmission and selection from evolving host responses. Genetic variation was investigated during persistent asymptomatic carriage of Neisseria meningitidis Interrogation of whole-genome sequences for paired isolates from 25 carriers showed that de novo mutations were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Fimbriae, Bacterial

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Source

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Identifiers

PMID: 32209693
DOI: 10.1128/mBio.03068-19
PMCID: PMC7157529

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Source receipt: pubmed, retrieved 7 Sept 2026.

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