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Article

BNC1 Promotes Spermatogenesis by Regulating Transcription of Ybx2 and Papolb via Direct Binding to Their Promotor Elements.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Mar 2021

Li Jing-Yi, Ying Yan-Yun, Qian Yu-Li, Chen Jian-Peng, Huang Yun, Liu Juan, Lv Ping-Ping, Liu Yi-Feng, Hu Xiao-Ling, Schilit Samantha L P, Sheng Jian-Zhong, Huang He-Feng, Zhang Dan

Abstract excerpt

BNC1 is a transcription factor that is crucial for spermatogenesis and male fertility, although the underlying mechanism remains unclear. To study BNC1's specific role in spermatogenesis, we characterized a previously developed mouse model carrying a truncating mutation in Bnc1 (termed Bnc1+/tr for heterozygotes and Bnc1tr/tr for homozygotes) and found that the mutation decreased BNC1 protein levels and resulted...

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PMID: 33211273
DOI: 10.1007/s43032-020-00342-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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