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Article

Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis.

Annals of the rheumatic diseases - 1 May 2017

Manetti Mirko, Romano Eloisa, Rosa Irene, Guiducci Serena, Bellando-Randone Silvia, De Paulis Amato, Ibba-Manneschi Lidia, Matucci-Cerinic Marco

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a transdifferentiation by which endothelial cells (ECs) lose their specific morphology/markers and acquire myofibroblast-like features. Here, we determined the possible contribution of EndoMT to the pathogenesis of dermal fibrosis in SSc and two...

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Identifiers

PMID: 28062404
DOI: 10.1136/annrheumdis-2016-210229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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