Article
In vivo analysis of Drosophila BLM helicase function during DNA double-strand gap repair.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
McVey Mitch
Abstract excerpt
The BLM helicase is a member of the RecQ DNA helicase family and is mutated in the cancer-prone disorder Bloom syndrome. BLM plays a role in a number of cellular processes including DNA double-strand break repair, Holliday junction dissolution, and chromosome segregation. In Drosophila melanogaster, the BLM ortholog (DmBlm) is encoded by the mus309 gene. To study the role of DmBlm in double-strand break repair,...
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