Article
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
Science (New York, N.Y.) - 30 Mar 2001
Kusano K, Johnson-Schlitz D M, Engels W R
Abstract excerpt
The Drosophila Dmblm locus is a homolog of the human Bloom syndrome gene, which encodes a helicase of the RECQ family. We show that Dmblm is identical to mus309, a locus originally identified in a mutagen-sensitivity screen. One mus309 allele, which carries a stop codon between two of the helicase motifs, causes partial male sterility and complete female sterility. Mutant males produce an excess of XY sperm and...
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