Article
Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning.
Molecular brain - 10 Nov 2020
Shirane Michiko, Shoji Hirotaka, Hashimoto Yutaka, Katagiri Hiroyuki, Kobayashi Shizuka, Manabe Toshiya, Miyakawa Tsuyoshi, Nakayama Keiichi I
Abstract excerpt
Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give rise to hereditary spastic paraplegia (HSP), the physiological role of the encoded protein has been largely unclear. We therefore generated mice deficient in protrudin and subjected them to a battery of...
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