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Article

Comprehensive molecular characterisation of hereditary non-polyposis colorectal tumours with mismatch repair proficiency.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2014

Bellido Fernando, Pineda Marta, Sanz-Pamplona Rebeca, Navarro Matilde, Nadal Marga, Lázaro Conxi, Blanco Ignacio, Moreno Victor, Capellá Gabriel, Valle Laura

Abstract excerpt

BACKGROUND: Hereditary non-polyposis colorectal cancer (CRC) without mismatch repair (MMR) defects occurs in almost half of high-risk CRC families, but its genetic cause(s) is(are) still unknown. We aimed to identify unique molecular features that differentiate hereditary from sporadic MMR-proficient colorectal tumours. METHODS: Genomic alterations in 16 tumours from 14 Amsterdam I-II families were studied using...

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Identifiers

PMID: 24841217
DOI: 10.1016/j.ejca.2014.04.022

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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