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Article

Functional differences between myeloid leukemia-initiating and transient leukemia cells in Down's syndrome.

Leukemia - 1 May 2010

Chen J, Li Y, Doedens M, Wang P, Shago M, Dick J E, Dick J, Hitzler J K

Abstract excerpt

Children with constitutional trisomy 21 or Down's syndrome (DS) are predisposed to develop myeloid leukemia (ML) at a young age. DS-ML is frequently preceded by transient leukemia (TL), a spontaneously resolving accumulation of blasts during the newborn period. Somatic mutations of GATA1 in the blasts of TL and DS-ML likely function as an initiating event. We hypothesized that the phenotypic difference between TL...

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Source

Identifiers

PMID: 20220775
DOI: 10.1038/leu.2010.30

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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