Article
The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression.
Molecular and cellular biology - 1 Oct 2007
Jia Junling, Lin Min, Zhang Lingna, York J Philippe, Zhang Pumin
Abstract excerpt
The size of an organ must be tightly controlled so that it fits within an organism. The mammalian lens is a relatively simple organ composed of terminally differentiated, amitotic lens fiber cells capped on the anterior surface by a layer of immature, mitotic epithelial cells. The proliferation of lens epithelial cells fuels the growth of the lens, thus controling the size of the lens. We report that the Notch...
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